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London, Jan. 21, 1905.
To the Editor:
—In an article entitled "The Control of Internal Hemorrhage by Drugs," Dr. Thomas Luther Coley says: "This group (nitroglycerin and the nitrites) has been recommended for pulmonary hemorrhage. It would seem, however, that the general widening of the blood paths, together with the fact that the heart beats more rapidly under the lowered pressure, would contraindicate its employment. The general widening of the blood paths will frequently increase the caliber of the vessels of the bleeding area."It is a question whether an increase in the caliber of the vessels of a bleeding area is of any importance in circumstances which provide for a fall of blood-pressure in that area. This, however, applies to hemorrhage from the systemic, not from the pulmonary, circulation. In the latter, it is highly improbable that an increase of caliber ever occurs through the action of the nitrites;
Hare F. Treatment of Hemoptysis. JAMA. 1905;XLIV(9):728. doi:10.1001/jama.1905.02500360060016
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