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March 11, 1905

Quinin in Pneumonia.

JAMA. 1905;XLIV(10):804. doi:10.1001/jama.1905.02500370052015

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Philadelphia, Feb. 25, 1905.

To the Editor:  —In reply to your correspondent's inquiry which you have referred to me concerning the use of enormous doses of quinin in pneumonia, as reported by Dr. Galbraith in The Journal, Jan. 28, 1905, p. 291, I would say that as a matter of theory I should have expected to kill, or certainly to injure, patients if I had given doses of 75 and 100 grains inside of two hours; but when a reputable physician reports the use of the drug in this heroic way in 50 cases without a death either from the disease or from the remedy, I am compelled to revise my theory. My only experience at all comparable is this: Some ten years ago, in the winter, I forget at the moment the exact date, I saw at about 12:30 a. m. a man 35 years of age

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