Although the kidney and liver unquestionably secrete important products into the blood, we have no definite anatomic provision for separate internal and external secretion, as is the case with the pancreas. Here we find that the cells which produce the chief internal secretion of the organ are anatomically distinct from those secreting the digestive juice, being collected in groups between the tubules to form the islands of Langerhans. It is not so generally understood that the testicle is in this respect quite similar to the pancreas. The tubular structures of the testicle are obviously concerned in the manufacture of the spermatozoa, the external secretion. Between the tubules, in addition to the connective tissue framework and vessels, are small collections of cells whose comparatively abundant, finely granular cytoplasm distinguishes them from the stroma cells, and at the same time suggests the possibility of secretory function. These cells are not as definitely
THE INTERNAL SECRETION OF THE TESTICLE.. JAMA. 1905;XLIV(11):876. doi:10.1001/jama.1905.02500380040004
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