This condition may be due to one or several causes. With the exception of inflammatory affections, neoplastic growths occupy a prominent position. With inflammatory thickening there exists an enlargement not only of the glands but of the tissues of the whole lip, and affecting one or both lips; there is no increase in the number of glands affected. Congenital dilatation of the lymphatic vessels, which is, more strictly speaking, an overgrowth when occurring in the tongue, produces macroglossia; when occurring in the lip, labium and other subcutaneous parts it is known as macrocheilia. Acquired lymphangiectasis is most commonly observed in the lower extremities and in the external genitals, being due to an obstruction of some nature and characterized by hyperplasia of the skin and subcutaneous tissues, producing the condition known as elephantiasis. Fraenkel1 states that prior to a case reported by him, macrocheilia due to a neoplasm of the mucous glands of
LINDENBERGER I. A CASE OF MACROCHEILIADUE TO ENLARGEMENT OF THE MUCOUS GLANDS OF THE LIP. JAMA. 1905;XLIV(12):959. doi:10.1001/jama.1905.92500390040003a
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