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March 25, 1905


JAMA. 1905;XLIV(12):963-964. doi:10.1001/jama.1905.02500390047007

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Up to the present our review has dealt chiefly with the researches bearing on the normal physiologic relations of uric acid, and we have, we believe, presented to our readers, though in very brief form, all of the important facts which may be considered as established in connection therewith. We desire now to turn to a consideration of the studies made on uric acid in disease, in other words, to the pathologic physiology of the substance. Though the discussion of this side of our topic will doubtless be even more interesting to our readers than that of the normal physiology, it is necessary to confess in the beginning that only a small number of definite facts on the pathologic side have thus far been accumulated, and that our knowledge of the significance of uric acid in pathologic processes is extremely fragmentary. In the researches on the pathology of uric

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