The correct estimation of the value of a given therapeutic agent in a given disease is often a difficult matter, on account of the many factors which must be taken into consideration in forming a judgment. In the treatment of new growths of a malignant character, the primary question to be considered is whether the suggested agent will completely destroy the focus of disease; then, if this question be answered in the affirmative, whether or not the destruction is as rapid and as free from risk as agencies already existing. In certain types of malignant neoplasm, early removal and freedom from risk may be accepted almost as synonymous terms, for the only risk of vital importance is the occurrence of metastases, and the danger of these secondary growths is often in direct ratio to the time which elapses between the discovery of the growth and its removal. In other forms
THE VALUE AND LIMITATIONS OF THE X-RAY TREATMENT OF MALIGNANT GROWTHS OF EPITHELIAL ORIGIN. JAMA. 1905;XLIV(12):965–966. doi:10.1001/jama.1905.02500390049012
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