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April 1, 1905


JAMA. 1905;XLIV(13):1029-1031. doi:10.1001/jama.1905.92500400033001e

A search through the chemical and physiologic literature will show that comparatively few complete analyses of urine, representing the full day's excretion, are on record. In the course of some other work, I found it necessary to make a number of lengthy determinations of this kind, and I present here the results obtained.

Beside the organic substances, urea, uric acid and creatinin, the urine contains essentially combinations of three inorganic acids and five inorganic bases. That is, there are combinations of sodium, potassium, ammonium, calcium and magnesium with hydrochloric, sulphuric, and phosphoric acids, the last two being largely products of oxidation metabolism. Some of the text-books of urine analysis and of physiology make rather misleading statements about the relations which exist between these substances and the limits within which they vary; and the old errors are still repeated in regard to the normal volume of urine excreted. It is the