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April 1, 1905


JAMA. 1905;XLIV(13):1039-1040. doi:10.1001/jama.1905.02500400043010

XII.  The suggestion of Wollaston1 that in some way or another uric acid is definitely related to the pathology of gout followed, as we have seen, his demonstration of the uratic nature of gouty deposits. It received unexpectedly great support about the middle of the last century through certain observations of Garrod, 2 which led that physician to conclude that the blood of gouty patients contains an abnormally large amount of uric acid.Garrod introduced what is known as the "thread test" for uric acid in the blood. To a little blood collected in a watchglass is added some dilute acetic acid; a linen thread is immersed in the mixture and the whole allowed to stand for twenty-four hours, evaporation being prevented. If the uric acid in the blood is increased, crystals of uric acid separate out, according to Garrod, adhere to the thread and can be recognized under