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April 8, 1905


JAMA. 1905;XLIV(14):1118-1119. doi:10.1001/jama.1905.02500410042005

Let us turn to the work which has been done on uricacid excretion in gout and see whether or not it permits us to draw any safe conclusions regarding the excess of uric acid now known to exist in the blood in this disease. In studying the physiologic side ofuric acid, we made considerable use, it may be recalled, of investigations of uric-acid excretion in health in order to gain ideas concerning the formation of uric acid in the normal body. We made the probably legitimate assumption that the amount of uric acid destroyed in the healthy body is a tolerably constant quantity, and, since the amount of uric acid excreted in health is the algebraic sum of the uric acid formed and the uric acid destroyed, we thought it justifiable to make important deductions regarding uric-acid formation from a study of the uric-acid excretion. This simple method, however, is

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