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April 8, 1905


JAMA. 1905;XLIV(14):1123. doi:10.1001/jama.1905.02500410047014

The subject of the chemical pathology of the nervous system is a recently opened field for investigation. In his lectures on biochemistry of muscle and nerve,1 the first Herter lectures in the University and Bellevue Hospital College in New York, Professor Halliburton reviews the work of Mott and himself on the chemical pathology of general paralysis of the insane. The attention was directed especially to the cerebrospinal fluid which, in this disease, is greatly increased in quantity in order to fill the place once occupied by the shrinking brain substance. It was found that the fluid from general paralytics contains an excess above the normal of proteid material (nucleoproteid) and, furthermore, that cholin is present not only in the cerebrospinal fluid but in the blood of these patients, which is not a normal occurrence. Now when nucleoproteid is injected intravascularly in certain animals it may produce thrombosis, and Halliburton