Although various therapeutic agents have been injected intramuscularly at different times, it was rather with the view of minimizing pain and of averting the formation of abscesses than of any expected increase in the rate of absorption. As a matter of fact, it was believed by some that the rate of absorption from the intramuscular tissues was slower than that from the subcutaneous tissues. It has been conclusively demonstrated, however, by Drs. S. J. Meltzer and John Auer1 that the relation of events is exactly the reverse and that the physiologic effects following intramuscular injection are only less prompt and less pronounced than those following intravenous injection. Observations were made with adrenalin, curare, fluorescein and morphin. The evidence shows that the fluid injected does not enter directly into the circulation, but is at first deposited between the muscular fibers, whence it is carried by some process of rapid absorption
THE RATE OF ABSORPTION FROM INTRAMUSCULAR TISSUE. JAMA. 1905;XLIV(15):1203. doi:10.1001/jama.1905.02500420047013
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