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April 15, 1905


JAMA. 1905;XLIV(15):1203. doi:10.1001/jama.1905.02500420047014

Granulations tingible with basic stains have been observed in the red blood corpuscles of the circulating blood especially in the presence of anemia, and they have been thought to represent a stage in the transformation of normoblasts into adult red corpuscles. Similar granulations, however, have been found also in the erythrocytes in cases of lead poisoning, and they have been induced experimentally by the administration of phenylhydrazin; and under such circumstances they have been attributed to a degenerative process of toxic origin involving the hemoglobin. The frequent presence of nucleated red corpuscles exhibiting various grades of nuclear degeneration suggests that the granules may represent fragments of disintegrated nuclei and that the morbid process may take place in the hemopoietic organs and not in the general circulation. Finally, basophilic granulations have been demonstrated in blood from normal individuals. In order to determine what relation, if any, exists between nucleated red corpuscles