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April 22, 1905

SOME FALLACIES IN THE AGGLUTINATION TESTSA PLEA FOR THE EMPLOYMENT OF A MORE UNIFORM TECHNIC.

JAMA. 1905;XLIV(16):1258-1262. doi:10.1001/jama.1905.92500430022001d
Abstract

The increased attention which has of late been extended to the serum agglutination of bacteria has brought into prominence certain fallacies which arise in the experimenter's hands, and which must have been noted, to a greater or less extent, by everyone working in this subject.

The literature which has now accumulated dealing with the agglutination of the typho-coli group alone is nigh unlimited, and many of the reports are so at variance with each other that we are landed in a hopeless confusion when we strive to draw the true inferences from them. Some have held that the agglutinine produced by each organism are specific, while a host of others have denied this and have pointed out that they are only special for closely allied groups of organisms. Others, again, have demonstrated that this agglutination reaction is not necessarily a vital one. but is also exhibited in inert substances

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