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Article
April 22, 1905

THE EXTRACTION OF THE INTRACELLULAR TOXIN OF THE COLON BACILLUS.WITH A PRELIMINARY STATEMENT CONCERNING ITS PHYSICAL AND CHEMICAL PROPERTIES.

Author Affiliations

Assistant in the Hygienic Laboratory of the University of Michigan. ANN ARBOR, MICH.

JAMA. 1905;XLIV(16):1271-1274. doi:10.1001/jama.1905.92500430035001g

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Abstract

INTRODUCTION.  The large tanks for the growth of bacteria in mass in use for some years in the hygienic laboratory of the University of Michigan permit the collection of bacterial cell substance in large amount and thus afford opportunity for the study of cellular chemistry not obtainable in any other way. Already several researches along this line have been carried on in this laboratory, and recently Dr. Vaughan has published his theory of the composition of bacterial cells and the principles of immunity developed from these studies. It is the purpose of this paper to detail some of the work which has been done recently in the extraction of bacterial intracellular toxins, with special reference to the toxin of the colon bacillus, and to give some preliminary statements concerning its physical and chemical properties. The method for the extraction of the toxin has been followed repeatedly and with

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