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During the summer of 1903 I had occasion to treat a family with diphtheria; one patient died from the laryngeal form after tracheotomy had been performed and large doses of antitoxin had been administered. An aunt acted as a nurse; she had exophthalmic goiter, with all the classic symptoms. No immunizing dose of antitoxin was given her, and she was infected with moderately severe pharyngeal diphtheria. I immediately injected 1,500 units of antitoxin and repeated the dose on the following day, combined with local antiseptic and internal supportive treatment, with the result that at the end of the week she was convalescent.
Four months later I saw this patient and noticed that the large tumor of the neck had disappeared, and that the eye symptoms were a trifle better. She stated that since the attack of diphtheria the goiter had grown smaller to such an extent that she noticed the
LEGGE RT. DIPHTHERIA ANTITOXIN IN THE TREATMENT OF GOITER.. JAMA. 1905;XLIV(16):1280–1281. doi:10.1001/jama.1905.92500430042003
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