The failure of studies of uric-acid excretion in gout to throw light on the cause of the excess of uric acid in the blood has been made evident. It now becomes necessary to ascertain whether or not studies of the total nitrogen metabolism or researches on the total phosphoric-acid metabolism in gout give us any help in connection with the problem referred to.
Certain earlier studies on the excretion of urea in gout may be neglected since in the determination no attention was paid to the nitrogen intake; moreover, these earlier investigations yielded contradictory results, some of them indicating that the amount of urea excreted in gout is increased, others that it is diminished.
The researches of Schmoll,1 in 1896, since confirmed by Magnus-Levy, Zagari and others, were among the first that attained to that degree of completeness which makes such studies valuable. Vogel had shown that the excretion
TRUTH AND POETRY CONCERNING URIC ACID. XIV.. JAMA. 1905;XLIV(16):1285–1286. doi:10.1001/jama.1905.02500430049008
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