Prior to Professor Koch's1 memorable address in 1901 a considerable amount of evidence had accumulated which seemed to indicate that the human and the bovine tubercle bacillus were not identical and that the former was incapable of causing a generalized tuberculosis in cattle. Not only had the earlier work of Bollinger,2 Chaveau, Günther and Harms, and others shown that the feeding of calves, swine and goats with human tuberculous material was unattended by ill effects in these animals, but, in more recent times, a number of experiments had been reported in which attempts to infect cattle with human tubercle bacilli were followed by absolutely negative results.
Baumgarten,3 who in 1891 sought to determine the identity of human tuberculosis and Perlsucht, failed to produce the slightest trace of tuberculosis in a calf which he inoculated with human tubercle bacilli, whereas the control calf which was infected with bovine tubercle bacilli died at the end of six weeks of acute general miliary tuberculosis.
VON RUCK S. THE INTEECOMMUNICABILITY OF HUMAN AND BOVINE TUBEECULOSIS. JAMA. 1905;XLIV(17):1350–1357. doi:10.1001/jama.1905.92500440001001e
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