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April 29, 1905

Special ArticleIMMUNITY.

JAMA. 1905;XLIV(17):1366-1369. doi:10.1001/jama.1905.02500440042002

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AMBOCEPTORS AND COMPLEMENTS.  The simplicity of hemolytic experiments and the rapidity with which they may be performed and terminated have rendered hemolytic serums particularly useful in the study of amboceptors and of complements, for we are to understand that such serums are toxic to erythrocytes only because of the amboceptors and complements which they contain. All the most important facts which have been learned concerning the action of hemolytic serums have been found to hold true for bactericidal serums as well; hence it is an indifferent matter if principles which are common to both are illustrated by frequent references to serum-hemolysins.The corpuscles for such experiments are obtained by the defibrination of freshly-drawn blood and the removal of the fibrin. Usually they are made into a 5 percent, suspension by dilution with isotonic Hemolytic (physiologic) salt solution. Inasmuch as the serum which is

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