The word goiter is used in a different sense by different writers, many of whom, like Orth, Wölfler and others, apply the term to all enlargements of the thyroid gland. Others restrict it to benign tumors of the thyroid, and by others again it is limited to hypertrophy only. Pratt1 suggests that it would be well to restrict the use of the word goiter to the endemic thyroid enlargements that occur in certain regions. He considers the classification of tumors of the thyroid of a benign character, not including the swellings of endemic nature. He classifies the growths that correspond in structure to normal thyroid tissue, and are classed by many as hypertrophies, as simple adenomas for the following reasons: First, it has been shown by Wölfler that such growths develop from embryonic rests in the stroma; second, many of the enlargements are circumscribed and sometimes encapsulated;
CLASSIFICATION OF BENIGN TUMORS IN THE THYROID. JAMA. 1902;XXXIX(5):261. doi:10.1001/jama.1902.02480310029010
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