Despite the discouraging results of the attempts to explain the excess of uric acid in the blood in gout by studies of uric-acid excretion, total nitrogen excretion, and phosphoric-acid excretion, investigators have tried in various other ways to get clues to the explanation of the phenomenon. Some have sought to show that the excretion of uric acid is faulty owing to disease of the kidneys, others that there is a retention owing to the occurrence in the blood either of a form of uric acid unsuitable for excretion or of conditions which are unfavorable to solution of ordinary uric acid and urates. and still others that there is an increased production of uric acid, oxidative or synthetic, owing to the hyperactivity of certain organs. No efforts have been made so far as we know to determine whether or not the destruction of uric acid which normally goes on in the
TRUTH AND POETRY CONCERNING URIC ACID. XV. JAMA. 1905;XLIV(17):1373–1374. doi:10.1001/jama.1905.02500440049009
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