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Article
August 9, 1902

THIOSINAMIN.CLINICAL AND EXPERIMENTAL OBSERVATIONS WITH REFERENCE TO CORNEAL OPACITIES AND OTHER OCULAR LESIONS.

JAMA. 1902;XXXIX(6):299-302. doi:10.1001/jama.1902.52480320009001c
Abstract

Mr. Chairman and Members of this Section:  Permit me to invite your consideration of an agent which of late has received considerable attention in the field of medicine and surgery. The writer alludes to thiosinamin. Perhaps it has received more notice, both as to published reports and clinical applications, in the foreign clinics than in this country.All the experiments and clinical applications of thiosinamin bear reference to its especial resolvent action upon cicatricial tissue. In this particular it has been used for the removal of keloids (Tousey, Newton), lupus (Hebra, Van Horn), urethral strictures (Newton), rheumatic joint affections (Upsam), and for various dermic lesions (Hebra, Sendziak). In studying the report of cases from the above class, it must be tacitly admitted that thiosinamin has a more or less specific action upon cicatricial tissue. This action is in the nature of a resolving or loosening.In view of the fact

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