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August 16, 1902


JAMA. 1902;XXXIX(7):371-373. doi:10.1001/jama.1902.52480330025001f

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The problem in therapeutics has been to discover some drug which would have an alterative effect upon the liver by increasing the excretion of its waste products of metabolism and arrested toxins by the bile, preventing the precipitation of cholesterin and pigments in the gallbladder, thereby preventing the formation of gallstones.

ORGANOTHERAPY.  In recent years organo-therapy has received a great amount of attention owing to the splendid results obtained by the administration of thyroid extract in myxedema and cretinism, and it is strange that more attention has not been paid to the bile acids which are undoubtedly one of the active principles of the liver, apparently utilized for the purpose of dissolving and holding in solution the excretory products of the liver and procuring their elimination by means of the bile into the intestine.Huppert, Rosenberg, Pfaff and Balch, Schaeffer and many other experimenters have proved conclusively that none of

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