Approximately two years ago the apparatus which has come to be generally known as the ultramicroscope was first described by Siedentopf and Zigmondy. Since then a number of contributions have been made relating to the application of this instrument in physico-chemical and biologic fields. While so far no very remarkable discoveries have been made, yet it may be stated that the instrument has found a definite place in chemical and biologic work and its field of usefulness is becoming more and more clearly defined and extended.
In bacteriology we should expect it to serve a valuable purpose in the study of those diseases which we now know are caused by a virus—presumably an organism—that will pass through a porcelain filter and therefore can not be seen by the aid of our ordinary microscopes. Rinderpest, foot and mouth disease, peripneumonia and probably also hog cholera and hydrophobia may be mentioned as
THE ULTRAMICROSCOPE AGAIN.. JAMA. 1905;XLIV(18):1450–1451. doi:10.1001/jama.1905.02500450038005
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