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The therapeutical results obtained by tuberculin may be summarized in two statements: 1. With the exception of certain forms to be specified hereafter, the agent exerts a specific effect on all tubercular lesions, by starting an inflammatory process in and around the tubercular tissue, which tends to cure the disease. 2. This reparative change has NOT proceeded up to the actual cure in the maiority of cases hitherto treated. The exceptions not influenced by tuberculin are old lesions in a state of caseation, a fact already pointed out by Koch in his first communication, but also fresh miliary eruptions, attention to which latter important observation has been called by Virchow and other pathologists. The inability of tuberculin to affect fresh miliary tubercles or to prevent their dissemination, and the frequent cessation of its curative influence before the infiltration has completely disappeared, are at present the main obstacles to success with
THE VALUE OF KOCH'S TUBERCULIN.. JAMA. 1891;XVI(19):672–673. doi:10.1001/jama.1891.02410710024005
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