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May 13, 1905


JAMA. 1905;XLIV(19):1535-1537. doi:10.1001/jama.1905.02500460043009

XVII.  We have reviewed in considerable detail, as we promised to do, the important work that has been done on this subject. The processes of uric-acid formation, excretion, destruction, retention, deposition and solution in health and disease have, one by one, been considered, and we have sifted as carefully as possible what we consider the wheat from the chaff. In a subject so complex it would be surprising if we did not include some worthless matter among the wheat and discard as refuse at least a little valuable grain. Despite the immense amount of work which has been done, it is surprising what a small bulk of well-determined fact has been accumulated and how much time and trouble have been required to prove the unreliability and harmfulness of a majority of the speculative views which have been advanced. Though the bulk of facts is not large, their value is precious,