In 1853 Alex. Wood1 of Edinburgh introduced hypodermic therapy. Mercurial injections were first administered by Charles Hunter and Barclay Hill,2 two Englishmen, in 1856. Hebra3 in 1864 made a vain effort to treat syphilis constitutionally by means of large injections of corrosive sublimate, and Scarenzio4 one year later carried on more successful and prolonged investigations by means of calomel injections suspended in gummatous solutions. All the above mercurial investigations, on account of the severe painful reaction induced by their administration, were short-lived, and would have doubtless remained unnoted and obscure had not Lewin5 aroused new and well-sustained interest in this now generally conceded important field of therapy, in 1868.
Mercury and mercury alone is the sheet anchor in the treatment of the earlier stages of syphilis. It matters not through what avenue the administration takes place, lungs, intestinal tract or skin, or in what particular form—metallic,
HEIDINGSFELD ML. INJECTION TREATMENT OF SYPHILIS BY MEANS OF A NEW MERCURIAL FORMULA.. JAMA. 1902;XXXIX(11):598–601. doi:10.1001/jama.1902.52480370006001a
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