Although the bacteriologic proof is wanting, there is clinical evidence in favor of the infectious character of chorea. The mode of invasion of the disease, its seasonal prevalence, its self-limitation, its liability to recurrence, its occasional fatal termination, the endocardial and articular complications or associations, the postmortem findings in some cases, all point in this direction. It is true that in a number of cases lesions, sometimes macroscopic, at other times microscopic, have been found in brain and cord, but their exact relation to the clinical manifestations has not been entirely clear, while the results of such bacteriologic examinations as have been made are lacking in uniformity. Thus, certain bodies thought to be characteristic have been described as present in the central nervous system. Again, emboli have been supposed to result from the endocarditis and give rise to softening in the brain and spinal cord. Further, changes have been found
THE PATHOGENESIS OF CHOREA. JAMA. 1902;XXXIX(11):633. doi:10.1001/jama.1902.02480370041004
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