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September 20, 1902


JAMA. 1902;XXXIX(12):702. doi:10.1001/jama.1902.02480380038003

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Specific lesions are often of importance in the diagnosis of disease. In a case of rabies a method of rapid diagnosis, by means of histologic examination of the nervous system for instance, has long been sought because of the importance of recognizing the existence of rabies in animals as well as in man. In the case of dogs, for instance, suspected to be mad, it may be of vital significance if a definite diagnosis of rabies could be established within two or three days. Babes held that the so-called rabic tubercle was pathognomonic of rabies. The rabic tubercle consists of an accumulation of cells, especially in the medulla and upper part of the spinal cord, around the central canal and about the motor cells. Various degenerations occur at the same time in the cells of the bulbar nuclei. Perivascular infiltration, commonly seen in many acute diseases, also

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