During the past few years there has been a great deal of investigation devoted to various phases of agglutination, and of late the agglutination of tubercle bacilli especially has received much attention. It seems that the principal result of the work on agglutination of tubercle bacilli so far as its practical application is concerned, may be summarized in the statement that the agglutination of tubercle bacilli does not occur constantly or regularly in tuberculosis. Consequently the reaction, at the present time at any rate, does not constitute a practicable, available diagnostic measure. This is the conclusion of Thellung,1 who has studied the question quite extensively and also experimentally. He finds that the subcutaneous injection of Koch's bacillary emulsion in doses of a few milligrams leads to the development of substances in the blood serum of the guinea-pig that agglutinate tubercle bacilli more markedly than the serum of non-tuberculous animals.
AGGLUTINATION OF TUBERCLE BACILLI AND NEW TUBERCULIN.. JAMA. 1902;XXXIX(12):705–706. doi:10.1001/jama.1902.02480380041009
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