It is well known that hysteria may simulate almost any form of organic disease of the nervous system, and that the differential diagnosis is by no means always easy. The difficulty is in nowise lessened by the fact that the two varieties of disease may be associated in the same patient. Of the numerous affections of the nervous system, none perhaps exhibits greater variability in symptomatology than multiple cerebrospinal sclerosis, and that this should be so will be easily understood from the nature and distribution of the lesions. In an interesting and instructive paper dealing with the early symptoms of insular sclerosis, Dr. E. Hobhouse1 takes the ground that hysteria is not rarely the prelude to this affection, and he states that it is exceedingly difficult in some cases to say where the one ends and the other begins, the disease often extending over a long period of years,
THE EARLY RECOGNITION OF INSULAR SCLEROSIS. JAMA. 1905;XLIV(20):1617–1618. doi:10.1001/jama.1905.02500470045006
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