Premise: All nephritis is toxic in origin, produced by the action on the kidneys of chemical or microbial toxins.
Under the name chronic nephritis are described slow inflammatory processes affecting both kidneys, due to a pathologic condition of the blood and leading to destruction of the parenchyma, with eventual shrinking of the organs. The most characteristic phenomenon of this affection, as pointed out by Senator, is not its termination in atrophy, but its casual relationship with hematic dyscrasia, for atrophy is met in other renal disease, as, for instance, in ascending nephritis. The cleansing of the blood of its impurities devolves mainly on the kidneys and it seems, therefore, evident that an abnormal condition of that fluid must be the chief source of renal affections. What the special form of hematic dyscrasia is that gives rise to lesions of the kidney, remains as yet unknown. It seems plain that the
ELLIOTT AR. ETIOLOGY OF CHRONIC NEPHRITIS.. JAMA. 1902;XXXIX(14):836–838. doi:10.1001/jama.1902.52480400030001h
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