Discussing so trite a subject as the diagnosis of chronic indurative or interstitial nephritis, one can scarcely do more than emphasize the importance of certain pathologic and clinical features of the disease—features that have significant diagnostic, prognostic and therapeutic bearings. It is impossible to add anything new to our knowledge of the subject. Indeed, as a matter of fact, we at this day are scarcely better informed on the subject than was Bright himself. It is true that Aetius (died 367 A. D.), Avicenna (980-1036), and Van Helmont (1577-1644) attributed certain cases of dropsy to disease of the kidneys, and that Cotunnius (1736-1822), in 1770, discovered that the urine of dropsical patients is coagulable by heating, but our first insight into the true nature of the nonsuppurative diseases of the kidneys was furnished by Richard Bright (1789-1858) in his memorable publications in 1827 and subsequently. It is also true that
KELLY AOJ. THE DIAGNOSIS OF CHRONIC INDURATIVE OR INTERSTITIAL NEPHRITIS.. JAMA. 1902;XXXIX(15):877–882. doi:10.1001/jama.1902.52480410001001
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