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October 11, 1902


Author Affiliations

Professor of Clinical Medicine, Philadelphia Polyclinic; Instructor in Clinical Medicine, University of Pennsylvania; Visiting Physician to the Philadelphia Hospital. PHILADELPHIA.

JAMA. 1902;XXXIX(15):883-892. doi:10.1001/jama.1902.52480410007001b

While the ultimate essence of uremia is unknown, everything points to the conclusion that the condition is a form of autointoxication, in whose production disease of the kidneys plays an important, but perhaps not the only rôle. The poison, like a number of others originating within the body, acts chiefly on the nervous system, although it is probable that no organ or tissue escapes its malign influence, inasmuch as it is conveyed to all parts of the economy by the blood.

VARIETIES OF APHASIA.  In their protean and variable character, the nervous manifestations of uremia are comparable to those of hysteria. † Like the latter, they are sometimes so distinctly focal as to suggest the existence of a gross organic cerebral lesion, which the autopsy, however, generally shows to be absent. Among these focal symptoms the most interesting are hemiplegia, monoplegia, monospasm and aphasia. Objectively these four manifestations of uremia