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October 11, 1902


JAMA. 1902;XXXIX(15):917. doi:10.1001/jama.1902.02480410041004

Until recently the pathogenesis of pernicious anemia belonged to the most obscure of medical problems. While far from elucidated as yet, the newer observations in regard to cellular toxins, especially the lysins, and still more particularly the hemolysins, seem to afford a new and secure basis from which to attack anew the problems of the evident excessive destruction of red corpuscles in this disease.

The simplest and most direct explanation of the excessive destruction of red corpuscles would be that it is due to the presence in the plasma of the blood of a hemolysin, whatever the origin of that substance might be. No one has demonstrated the appearance of any special autohemolysin in the blood of patients with the disease, however, and the conditions are probably not so simple as suggested. Continuing for a moment this thought of a special hemolysin, the next step would be to produce an