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November 1, 1902


JAMA. 1902;XXXIX(18):1118. doi:10.1001/jama.1902.02480440038005

There is much of fundamental interest in the recent publication on "Tuberculosis" from Behring's Institute in Marburg,1 in which are reported the results of the investigations of the last five years by Behring and his assistants Römer and Ruppel. Indeed, if we mistake not, the solutions are here given of some of the fundamental problems in tuberculosis. The most important of these is undoubtedly the one concerning immunity to tuberculosis. Behring shows that by repeated injections of cattle with cultures of human tubercle bacilli that are comparatively harmless for cattle, there is produced a complete immunity to virulent bovine tubercle bacilli, bacilli so virulent that 2½ milligrams injected intravenously causes death in two to three weeks from acute miliary tuberculosis of the lungs. Behring designates this method of immunization as "jennerization." Animals immunized in this way withstand well the intraocular injection of virulent tuberculous material which so injected in