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As might have been expected, it has been found that horses do not all react alike in response to inoculations with diphtheria-toxin for the purpose of producing antitoxin, and no method is yet known by which high-test horses can be selected without being submitted to the tedious process of immunization. It has been shown that every horse has a maximum antitoxic limit, which can not be increased no matter how much toxin is employed. As the outcome of a study of the records of 100 horses immunized to diphtheria-toxin, Dr. William R. Hubbert1 found that in order to obtain the best results in the production of diphtheria-antitoxin, young animals are usually to be preferred. More than one half the number of such horses can be made to yield 300-unit serum, while one-third will yield 500-unit serum. High-test horses require a shorter time for immunization and will yield a potent
THE COMPARATIVE VALUE OF HORSES IN THE PRODUCTION OF DIPHTHERIA ANTITOXIN. JAMA. 1905;XLIV(22):1785. doi:10.1001/jama.1905.02500490061013
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