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November 8, 1902


JAMA. 1902;XXXIX(19):1167-1173. doi:10.1001/jama.1902.52480450017002d

Two notable contributions on the morbid anatomy of hepatic syphilis, the one by Adami1 the other by Flexner,2 render superfluous any review which I might make of this part of the question. Although the chief pathologic changes induced by syphilis of the liver appear to have been carefully studied and classified, the clinician occasionally meets with instances of undoubted syphilis in which there develop hepatic manifestations that so puzzle him as to the precise character of the morbid change that classification has to be abandoned. There is abundant literature of the classical expressions of the disease with which all recognized students substantially agree, and there are to be found many scattered reports of individual cases that are sufficiently rare to warrant description; but these are so commonly benefited by treatment that they either escape autopsy altogether or else are delayed until the specific effects of mercury or iodid