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November 8, 1902


JAMA. 1902;XXXIX(19):1187. doi:10.1001/jama.1902.02480450037004

The recent successful bacteriologic studies of the blood in typhoid fever have given us such results that some of the older conceptions of the nature of this disease must be remodeled. It appears from these investigations, of which there is now at hand a goodly number from various places, that bacilli may be cultivated from the blood in more than 80 per cent, of the cases and that the earlier in the disease the examination is made the greater the frequency of bacilli in the blood.

This perhaps at first somewhat unexpected turn of events is largely due to modifications in the technic employed. In the earlier part of the bacteriologic study of typhoid fever only small quantities of blood were used, and generally the inoculations were made directly on solid media or in small quantities of broth. Such small quantities of blood—at most a few drops—might not happen to