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November 15, 1902


JAMA. 1902;XXXIX(20):1257-1258. doi:10.1001/jama.1902.02480460035004

It seems clear now that there must be accepted a group of affections very similar to typhoid fever clinically, yet due to an essentially different etiologic factor. The cases of so-called typhoid fever affecting about 5 per cent. of all the patients presumed to be suffering from that disease in which no Widal reaction can be obtained, either during the course of the fever or the convalescence, are, in the light of recent investigations, due, not to the Gaffky-Ebert bacillus, but to a microorganism of the colon bacillus family, having many morphologic and cultural similarities to the genuine Bacillus typhosus. The work done in elaborating distinctions between these closely allied bacillary groups which has occupied so many minds for so many years is now to have its reward, for certain at least of the colon family are to be recognized as playing a distinct specific pathologic rôle in the enteric