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June 10, 1905

Special Article

JAMA. 1905;XLIV(23):1853-1854. doi:10.1001/jama.1905.02500500033002

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IMMUNITY.  CHAPTER XVI.—Concluded from Page 1683.If an immune animal receives an intravascular injection of the vibrio of cholera and is sacrificed shortly, the relation of the organisms to the leucocytes may be studied in stained microscopic sections of the organs (lungs). Leucocytes which have undergone phagolysis are seen to be clumped in the pulmonary vessels and in their immediate vicinity one finds many micro-organisms which have been changed into the characteristic granules by the action of the cytase which has escaped from adjacent leucocytes. Coincident with the phenomenon of phagolysis the leucocytes lose their phagocytic power, hence no bacteria are found within the leucocytes. On the other hand, all those vibrios which are remote from the leucocytes have a perfectly normal appearance. Phagolysis in the blood stream may be prevented, just as in the peritoneal cavity, by a preceding injection of bouillon. In this instance when the

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