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It is usually considered that amenorrhea, especially if it asserts itself after menstruation has once been thoroughly established, is due to some affection of the genital tract. As a matter of fact, however, the cessation is more likely to be the consequence of some systemic disease. The cessation of the menses in young women may be the first signs of tuberculosis, when there is otherwise little general disturbance of the health. As a matter of fact, menstruation and the menstrual period in women present conditions, modifications of which in various ways point more often to an active tuberculous process in the system than almost any other set of symptoms. Recently it has been noted that chlorosis is reported much less frequently than used to be the case, and there would seem to be a lessening of the prevalence of this blood affection in America. It has been suggested, however, that
AMENORRHEA AND SYSTEMIC DISEASE. JAMA. 1905;XLIV(23):1859–1860. doi:10.1001/jama.1905.02500500039008
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