Studies of the typical internal secretions of glands, and of the career of foodstuffs in the many changes they undergo before completing the round of metabolism, have made general the knowledge of the interdependence of the organs, and for that matter of the cells, on each other. It is because of this interdependence that a failure on the part of one group of cells often leads to changes in a remote group, the results of which may overshadow the results from the original lesions. Likewise, the "vicious circle" may be developed by the failure of one sort of metabolic change throwing an entirely different but dependent process out of action, which in turn interferes with the already abnormal process that first became disordered. Such examples of interdependence are rather obscure and indefinite to serve as illustrations of an important principle, and perhaps more simple and interesting examples are furnished in
THE INTERRELATION OF CELLS AND ORGANS. JAMA. 1902;XXXIX(22):1394–1395. doi:10.1001/jama.1902.02480480036002
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