The condition of enlargement of the spleen with anemia has attracted a good deal of attention within recent years. It has been given a number of different names and no doubt different affections have been described under the same name. Despite the careful study to which the disorder has been subjected there is no unanimity of opinion as to its nature and origin. Osier defines the affection as a special malady of unknown etiology, characterized by a chronic course, enlargement of the spleen, anemia of a secondary type, a marked tendency to hemorrhage from the stomach and a liability to be associated in the late stages with jaundice, cirrhosis of the liver and ascites. He considers it probable that the conditions described separately in the literature as primitive splenomegaly, splenic anemia and splenomegalic cirrhosis of the liver or Banti's disease, are stages of one and the same malady.
SPLENIC ANEMIA.. JAMA. 1902;XXXIX(22):1395–1396. doi:10.1001/jama.1902.02480480037004
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