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Article
December 13, 1902

THE ROLE OF THE TOXINS IN INFLAMMATORY PROCESSES.

JAMA. 1902;XXXIX(24):1526-1527. doi:10.1001/jama.1902.02480500032003
Abstract

The time has probably arrived when the pathologist should insist that the professional gaze shall no longer be directed to pathogenic bacteria as the sole agent in the production of inflammation. For many years we have known that infective alterations in the tissues are not always to be explained by the presence of bacteria, although it is also well established that the initial disturbance is very frequently due to microbic invasion. One of these numerous instances is found in migratory ophthalmia. This example is chosen because it well exemplifies the progress made in very recent times in the domain of bacteriology. The experiments of Harold Gifford, Deutschmann and others have clearly shown that the path of infection in "sympathetic" ophthalmia is along the vaginal canals (and other lymph spaces) of the optic nerve, from the injured and infected eye to the chiasma, thence, by way of the opposite nerve, to

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