The careful and systematic study of any one of the chronic convulsive disorders is certain to throw much light on all. The problem of discovering their nature and pathology must rest largely in the future on the correlation of such studies. The gradual change of the location of the lesion of convulsive diseases from the muscle, peripheral nerve, medulla and basal ganglia to that of the cerebral cortex has been brought about largely through detailed studies on isolated cases.
It is of particular interest to note that much of the newer work on the pathology of many so-called functional disorders, such as epilepsy, chorea, convulsive tics, myoclonies and the like, brings them more nearly to a common pathology and pathogenesis; that is, to an organic basis with a definite cortical lesion, degenerative in type. This has been well shown in the work of Clark and Prout1 on status epilepticus,
THE PATHOLOGY OF CONVULSIVE DISORDERS. JAMA. 1902;XXXIX(24):1527–1528. doi:10.1001/jama.1902.02480500033004
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