The results of operative treatment of malignant disease, even under the most favorable conditions, are on the whole so discouraging that it is not surprising that cases which are clearly thought to be inoperable are frequently neglected. The large number of patients who fall a prey to quacks because of such neglect makes it the imperative duty of a practitioner to try every known means of alleviation, if not of cure, for these distressing cases. Means which have been employed with more or less success are numerous. Coley's serum is among the best known of such curative agents, and has undoubtedly cured a number of cases of spindle-celled sarcoma. It has not proved of any value in the treatment of carcinoma or of most other forms of sarcoma, and like other means of this kind should not be employed except in inoperable cases. Oöphorectomy in cases of carcinoma of the
TREATMENT OF INOPERABLE MALIGNANT DISEASE. JAMA. 1902;XXXIX(24):1528–1529. doi:10.1001/jama.1902.02480500034005
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