We know a number of familiar antiseptic substances that quickly destroy pathogenic bacteria with which they are brought in contact outside the body. From time to time it has been proposed to introduce such antiseptics into the body in order to directly attack general infections, like puerperal septicemia, acute endocarditis and the like. The substances that exercise such prompt bactericidal effect in the test tube might have like action in the living organism harboring infectious organisms. Unfortunately, the conditions in the living body are so infinitely more complex than in the mixtures of the test tube that we long ago learned not to apply the results obtained in the latter to actual infections, and yet the necessity for efficient and otherwise harmless "internal antiseptics" has led to more or less effort to establish by empirical methods the usefulness of certain substances of this class.
Perhaps Credé's colloid silver (collargol) has
ANTI-INFECTIOUS ACTION OF CREDE'S COLLARGOL. JAMA. 1902;XXXIX(25):1598. doi:10.1001/jama.1902.02480510038002
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