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June 24, 1905

Special ArticleIMMUNITY. CHAPTER XVII (Concluded).

JAMA. 1905;XLIV(25):1987-1989. doi:10.1001/jama.1905.02500520015002

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THE SIDE-CHAIN THEORY OF EHRLICH AND ITS RELATION TO THE THEORY OF PHAGOCYTOSIS.  Third tenet: Is there any direct experimental proof that those constituents of cells which have been designated as cell receptors actually undergo multiplication in the cell itself as a preliminary to their discharge into the circulation in the form of antibodies? If this condition could be demonstrated in one instance, one might reasonably consider that it typifies a law according to which all antibodies are formed. Further experiments by von Dungern with the precipitins seem to show that such intracellular overproduction actually does occur. The experiments concern the fate of "Majaplasma" (plasm of the crawfish) when injected into the circulation of the rabbit (see above). If a single injection of the serum is given, a specific precipitin for the latter body in due time may be demonstrated in the serum

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