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It sounds somewhat contradictory to say that a papilloma can develop from a surface which is not naturally supplied with papillae. At first it would seem impossible, but the vagaries of neoplasms are numerous, and this seems to be one of them.
Von Ziemssen, in Ziemssen's Archives, Vol. vii, in speaking of papillÆ of the larynx, says:
"The development of papillary growths occurs not only off the mucous surface originally provided with papillÆ, but, as is especially shown by Virchow (Krankhafte Geschwulste, 1, pp 334 and following), also in regions where papillary structure of the mucous membrane is entirely lacking. The first step is the proliferation of the superficial connective tissue, the development of a little amorphous granular or homogeneous nodule, in which cells are not to be recognized until later. As the cells multiply, they gradually grow and put forth buds, just as is done by the preëxisting papillae
AYRES SC. PAPILLOMA OF THE CORNEA, WITH REPORT OF A CASE.Read in the Section of Ophthalmology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.. JAMA. 1891;XVII(12):442–444. doi:10.1001/jama.1891.02410900018001b