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In view of the prevalence of gonorrhea and of the obstinacy of this disease to treatment, all new facts in regard to the biology of its microbe must be of interest. De Christmas and others have demonstrated that the gonococcus elaborates toxic substances capable of producing suppuration and fever in animals, and a purulent urethritis in man. The latter is characterized by abundant pus formation and heals spontaneously in a few days. The toxic substance or substances are found partly in the bodies of the cocci, partly dissolved in the liquid of the culture medium. De Christmas states that animals may be immunized against the toxin by the inoculation of successively increasing doses thereof. These observations have been questioned by other writers who found the gonococcus more or less feeble in its power to produce toxin. Evidently the composition of the medium upon which it is grown plays an important
THE TOXIN OF THE GONOCOCCUS. JAMA. 1900;XXXV(1):36. doi:10.1001/jama.1900.02460270044012
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